The interplay between Staphylococcus aureus two-component systems and phages

PhD defence by Jack Åke Harry Abrahamsson

Assessment Committee

Professor Lone Brøndsted, Department of Veterinary and Animal Sciences, University of Copenhagen (Chairperson)
Professor Birgitte Haahr Kallipolitis, University of Southern Denmark
Professor Andreas Peschel, University of Tübingen

Supervisors

Professor Hanne Ingmer
Professor Christian Adam Olsen
Associate Professor Keira Melican

Department

Department of Veterinary and Animal Sciences

Graduate Programme

Veterinary, Animal Health and Microbiological Sciences

Place

The defence is conducted as a hybrid defence.

To attend the defence in person:
Building: 1-01, Room: A1-01.01,
Bülowsvej 17, 1870 Frederiksberg C

To attend the defence online:
Please follow the link to attend the defence online: https://ucph-ku.zoom.us/j/63680786027?pwd=V9UEpZ0d9UP3Xjz8umgbTQVzJPLGq9.1
MeetingID, if relevant: 636 8078 6027
Password, if relevant: 659640

Email address to gain access to the thesis: jack.abrahamsson@sund.ku.dk.
You will either receive a copy of the thesis or be informed where you can read a physical copy.
Recipients of copies of the thesis are not allowed to share or distribute it due to copyright compliance.

Short description of the thesis

Staphylococcus aureus is one of the world's most problematic bacterial pathogens, causing diseases that range from minor skin infections to life-threatening conditions like sepsis while becoming harder to treat with antibiotics. This thesis explores how regulatory systems that control bacterial virulence and antibiotic resistance also affect susceptibility to bacteriophages, viruses that infect bacteria. By examining the interplay between these processes, the work improves our understanding of connections that influence the effectiveness of both antibiotics and phages, providing knowledge that may support development of future treatment strategies against S. aureus infections.