Optimizing PCI Strategies in STEMI With and Without Cardiogenic Shock
PhD defence by Jasmine Melissa Marquard
Assessment Committee
Professor Kasper Karmark Iversen, Department of Clinical Medicine, University of Copenhagen (Chairperson)
Associate professor Troels Thim, Aarhus University Hospital and Aarhus University
Professor Gianluca Campo, University of Ferrara
Supervisors
Clinical Professor Thomas Engstrøm
Clinical Associate Professor Jacob Thomsen Lønborg
MD Emil Roelsgaard Obling
Department
Department of Clinical Medicine
Graduate Programme
Cardiovascular Research
Place
The defence is conducted as a hybrid defence.
To attend the defence in person:
Building: Opgang 93, Rigshospitalet, Room: Auditorium 93,
Henrik Harpestrengsvej 4B, 2100 Copenhagen Ø
To attend the defence online:
Please follow the link to attend the defence online:
https://teams.microsoft.com/meet/382073950654286?p=ALgDJNT63c1Hm4pOff
MeetingID, if relevant: 382 073 950 654 286
Password, if relevant: YA3Fd3es
Email address to gain access to the thesis: jasmine.melissa.marquard@regionh.dk.
You will either receive a copy of the thesis or be informed where you can read a physical copy.
Recipients of copies of the thesis are not allowed to share or distribute it due to copyright compliance.
Short description of the thesis
Primary PCI has transformed STEMI care, yet one-year mortality has plateaued and cardiogenic shock remains associated with mortality of up to 50%. This thesis examines whether revascularization in STEMI should be individualized according to culprit-lesion morphology, non-culprit disease burden, coronary complexity, and hemodynamic state. Five questions are addressed: whether culprit-lesion stenting can be safely omitted in selected patients; whether FFR-guided complete revascularization confers durable benefit in multivessel disease; whether immediate multivessel PCI improves outcomes in STEMI-related cardiogenic shock; whether baseline and residual coronary complexity predict mortality in shock; and whether coronary anatomy modifies the effect of microaxial flow pump support. Together, these studies aim to inform a phenotype-guided approach to revascularization in STEMI.