Investigations of impaired subcutaneous adipose tissue expandability in low birth weight men

PhD defence by Line Ohrt Elingaard-Larsen

Assessment Committee

Professor Steen Bendix Haugaard, Department of Clinical Medicine, University of Copenhagen (Chairperson)
Dr Anne Loft, University of Southern Denmark (SDU)
Professor Susan Ozanne, University of Cambridge

Supervisors

Clinical Professor Jørgen Rungby
Senior Researcher, Team leader Charlotte Brøns
Affiliate Professor Allan Arthur Vaag

Department

Department of Clinical Medicine

Graduate Programme

Basic Metabolic Research

Place

Building: Steno Diabetes Center Copenhagen, Room: Auditorium (Lokale 1.37), Borgmester Ib Juuls Vej 83, 2730 Herlev

Email address to gain access to the thesis: line.ohrt.elingaard-larsen.01@regionh.dk.
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Short description of the thesis

Can the foundation for developing Type 2 Diabetes be established during fetal life?

This thesis explores how an unfavorable fetal environment, reflected by low birth weight, can leave long-lasting biological marks that affect metabolism throughout life. Focusing on adipose tissue and the body's ability to store excess energy safely, the thesis investigates why individuals born with a low birth weight are more likely to develop type 2 diabetes and fatty liver disease, especially when exposed to calorie-rich diets. The thesis further examines whether these effects are linked to changes in fat cells established during fetal development.