Beyond Appetite Suppression and Weight Loss Quantity: The Role of a Dual Amylin and Calcitonin Receptor Agonist

PhD defence by Emilie Ahmt Visbech

Assessment Committee

Associate professor Trisha Jean Grevengoed, Department of Biomedical Sciences, University of Copenhagen (Chairperson)
Professor Niels Jessen, Aarhus University
Professor Eric Ravussin, Louisiana State University

Supervisors

Associate Professor Steen Larsen
Professor Kim Henriksen
PhD, Scientist Anna Larsen
Professor Jørn Mikael Wulff Helge

Department

Department of Biomedical Sciences

Graduate Programme

Basic and Clinical Research in Musculoskeletal Sciences

Place

The defence is conducted as a hybrid defence.

To attend the defence in person:
Building: Bygning 20, stuen, Room: Victor Haderup Auditoriet,
Blegdamsvej 3B, 2200 København N

To attend the defence online:
Please follow the link to attend the defence online:

https://teams.microsoft.com/meet/384822270555120?p=kg5JcWL0vWXWnlnpRE

MeetingID, if relevant: 384 822 270 555 120
Password, if relevant: HZ33Ez9K

Email address to gain access to the thesis: emilieahmt@sund.ku.dk.
You will either receive a copy of the thesis or be informed where you can read a physical copy.
Recipients of copies of the thesis are not allowed to share or distribute it due to copyright compliance.

Short description of the thesis

Obesity is one of the current major health challenges, and new therapies can induce weight loss exceeding 20% of body weight. However, this weight loss often comes with unintended consequences, including loss of muscle mass and a reduction in energy expenditure, which may challenge long-term maintenance of the weight loss. This PhD thesis investigates a promising candidate for the treatment of obesity, a dual amylin and calcitonin receptor agonist, and its potential to support a healthier and more sustainable weight loss. By examining its effects on energy expenditure, muscle health, fat oxidation, and weight regain, this research aims to advance the development of next-generation obesity therapies.