Adventures into the Chemistry Realms of Cucurbiturils and Helicenes

PhD defence by Jeppe Schjær Mogensen

Assessment Committee

Professor Morten Meldal, Choose..., University of Copenhagen (Chairperson)
Professor Kurt Vesterager Gothelf, Aarhus University
Professor Agnieszka Nowak-Król, University of Würzburg

Supervisors

Professor Rasmus Prætorius Clausen
Professor Michael Pittelkow

Department

Department of Drug Design and Pharmacology

Graduate Programme

Pharmaceutical Sciences

Place

Building: 3, Room: Auditorium 2, HCØ, Universitetsparken 5, Copenhagen Ø 2100

Email address to gain access to the thesis: jeppe.jensen@sund.ku.dk.
You will either receive a copy of the thesis or be informed where you can read a physical copy.
Recipients of copies of the thesis are not allowed to share or distribute it due to copyright compliance.

Short description of the thesis

Cucurbiturils and helicenes are two fascinating and distinct molecular structures with unique properties. In this dissertation, the synthesis and properties of these types of molecules are explored. Site-selective functionalization of proteins and peptides through an affinity-guided approach using the selective recognition of aromatic N-terminal amino acids by cucurbit[7]uril (CB[7]) is presented. Furthermore, acyclic cucurbiturils are investigated as solid-state sequestrants for organic micropollutants. Finally, the focus is shifted to helicenes, where benzofuran scaffolding is explored for the synthesis of progressively elongated helicenes with enhanced chiroptical properties.