Advancing molecular oncology in dogs - Comparative genomics, circulating tumour DNA, and pharmacogenetics

PhD defence by Monica Nielsen

Assessment Committee

Associate professor Camilla Vibeke Sichlau Bruun, Department of Veterinary and Animal Sciences, University of Copenhagen (Chairperson)
Associate professor Iben Lyskjær Heimann, Aarhus University
Professor Peter James Dickinson, UC Davis Weill School of Veterinary Medicine

Supervisors

Professor Maja Louise Arendt
Professor Hanne Birgit Gredal

Senior Group Leader David Adams

Department

Department of Veterinary Clinical Sciences

Graduate Programme

Clinical Cancer Research

Place

Building: Universitetshospitalet for familiedyr, Room: Orangeriet, Dyrlægevej 16, 1870 Frederiksberg C

Email address to gain access to the thesis: moni@sund.ku.dk.
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Short description of the thesis

Better and safer cancer therapy for dogs depends on continued advances in molecular oncology. This thesis presents three molecular studies addressing complementary aspects of the field: tumour biology, minimally invasive tumour profiling and pharmacogenetics. The first study examines meibomian gland adenomas, common benign eyelid tumours in dogs. It identifies molecular drivers shared with benign sebaceous tumours in humans. The second shows that circularing tumour DNA in cerebrospinal fluid captures genetic features of intracranial neoplasms. The third identifies a genetic variant in Skye terriers that may affect how these dogs tolerate certain medications. Together, these studies support the continued development of more personalised cancer care for dogs.