Type 2 inflammation in COPD: Prevalence, Clinical Phenotypes and Implications for Management

PhD defence by Sigrid Brisson Nielsen

Assessment Committee

Professor Charlotte Suppli Ulrik, Department of Clinical Medicine, University of Copenhagen (Chairperson)
Professor Ulla Møller Weinreich, Department of Respiratory Diseases, Aalborg University
Professor Frits Franssen, Faculty of Health, Medicine and Life Sciences, Pulmonologie NUTRIM - Healthy Ageing, Maastricht University

Supervisors

Associate Professor Asger Sverrild
Celeste Michala Porsbjerg
Therese Laperre

Department

Department of Clinical Medicine

Graduate Programme

Public Health and Epidemiology

Place

Building: Building 12, Room: Lassen Auditoriet, Bispebjerg Hospital, Nielsine Nielsens Vej 12, 2200 Copenhagen

Email address to gain access to the thesis: sigridbrisson@hotmail.com.
You will either receive a copy of the thesis or be informed where you can read a physical copy.
Recipients of copies of the thesis are not allowed to share or distribute it due to copyright compliance.

Short description of the thesis

Chronic obstructive pulmonary disease (COPD) is a common lung disease affecting millions of people worldwide, yet patients can differ greatly in how the disease develops and responds to treatment. This PhD thesis explores the role of type 2 (T2) inflammation, a specific inflammatory pathway that may help explain this variation and support more personalised treatment. By studying patients with COPD in real-world clinical settings, the thesis investigates how T2 inflammation relates to disease characteristics, exacerbations, and disease instability. The findings demonstrate that inflammatory biomarkers provide information beyond conventional clinical assessment and highlight the importance of identifying modifiable factors contributing to disease instability, with the potential to improve future COPD management.