PhD defence by Lone Musaeus Poulsen

Functional status of intensive care unit patients - Pre-admission status and outcomes

Assessment Committee:
Associate professor Anne Juul Wikkelsø, Department of Clinical Medicine, University of Copenhagen (Chairperson)
Professor Michael Haney, Umeå University
Professor Niklas Nielsen, Lund University

Supervisors:
Clinical Professor Ole Mathiesen
Professor Bodil Steen Rasmussen
MD, PhD Stine Estrup Damby

Department:
Department of Clinical Medicine

Graduate Programme:
Surgical Sciences

Place:
Sjællands Universitetshospital Køge, Room: Auditorium, Lykkebækvej 1, 4600 Køge

Email address to gain access to the thesis: lmp@regsj.dk 
You will either receive a copy of the thesis or be informed where you can read a physical copy.

Short description of the thesis:
The overall aim of this thesis was to investigate functional status in patients admitted to the ICU, as preadmission status, and long-term outcome. In a systematic review, we provided an overview of evidence on functional measures used to assess preadmission status and demonstrated their association with mortality through meta-analysis. We developed two mortality prediction models using machine learning techniques and multivariate regression in a delirium cohort from the AID-ICU trial and a single-centre ICU cohort, respectively, and demonstrated that functional measures were strong predictors. Finally, we investigated functional status one year after randomisation to the AID-ICU trial.