Hyperglycaemia in patients with severe acute brain injury

Hyperglycaemia in patients with severe acute brain injury

PhD defence by Anne-Sophie Worm Fenger

Assessment Committee

Associate professor Tina Nørgaard Munch, Department of Clinical Medicine, University of Copenhagen (Chairperson)
Associate professor Esben Søndergaard, Department of Clinical Medicine, Medical/Steno Aarhus Research Laboratory, Aarhus University
Professor Jeroen Hermanides, Department of Anesthesiology Amsterdam University Medical Center

Supervisors

Professor Kirsten Møller
Rikke Krogh-Madsen
Signe Tellerup Nielsen

Department

Department of Clinical Medicine

Graduate Programme

Neuroscience

Place

Building: 93, Room: Auditorium 93, Blegdamsvej 9, 2100 København Ø

Email address to gain access to the thesis: anne-sophie.fenger.03@regionh.dk.
You will either receive a copy of the thesis or be informed where you can read a physical copy.
Recipients of copies of the thesis are not allowed to share or distribute it due to copyright compliance.

Short description of the thesis

Hyperglycaemia is common among critically ill patients admitted to intensive care units and is associated with increased risk of morbidity and mortality. This PhD thesis investigates hyperglycaemia in patients with severe acute brain injury, including traumatic brain injury and subarachnoid haemorrhage. The thesis comprises a systematic review comparing restrictive versus liberal blood glucose targets, a retrospective cohort study examining the relationship between blood glucose and cerebral microdialysis glucose, and two clinical studies conducted at the Neurointensive Care Unit at Rigshospitalet. These studies explore the clinical significance of hyperglycaemia, the potential modifying effect of premorbid diabetes, and the short-term physiological effects of hyperglycaemia on cerebral glucose metabolism.
Together, these studies aim to improve the understanding of glucose metabolism after severe acute brain injury.