Cellular and molecular signatures for forensic age assessment of granulation tissue

PhD defence by Cecilie Bækgård

Assessment Committee

Professor Louise Kruse Jensen, Department of Veterinary and Animal Sciences, University of Copenhagen (Chairperson)
Professor Peter M. H. Heegaard, Technical University of Denmark
Associate professor Rob J. Vreeken, Maastricht University

Supervisors

Professor Henrik Michael Elvang Jensen
Kerstin Skovgaard
Assistant Professor Eva Cuypers

Department

Department of Veterinary and Animal Sciences

Graduate Programme

Immunology and Infectious Diseases

Place

Building: 1-01, Room: A1-01.01 (Festauditoriet), Bülowsvej 17, 1870 Frederiksberg

Email address to gain access to the thesis: cecb@sund.ku.dk.
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Short description of the thesis

Accurate wound age assessments are of utmost importance in veterinary forensic pathology. Current age assessments are based on the thickness of granulation tissue and histological evaluation. However, these wound age estimations are based on incomplete scientific evidence. The aim of the project was to identify time-dependent cellular and molecular signatures to improve the accuracy and objectivity of wound age estimations in veterinary forensic investigations. Granulation tissue from experimental porcine wounds and forensic cases were evaluated using multiple methods (gross pathology, histology, IHC, flow cytometry, qPCR, MALDI-MSI and LC-MS).