PhD defence by Tamo Sultan

Type 2 Inflammation and Symptom-Based Phenotypes in Childhood Asthma

Assessment Committee:
Professor Klaus Gottlob Müller, Department of Clinical Medicine, University of Copenhagen (Chairperson)
Professor Sejal Saglani, Head of the Inflammation, Repair and Development Section at the National Heart and Lung Institute, Imperial College London
Professor Mika Mäkelä, Department of Allergy, Helsinki University Hospital and University of Helsinki

Supervisors:
Clinical Professor Klaus Bønnelykke
Clinical Professor Bo Lund Krogsgaard Chawes
Postdoctoral researcher Nicklas Brustad
Clinical Research Associate Professor Ann-Marie Malby Schoos
Associate Professor Jakob Stokholm

Department:
Department of Clinical Medicine

Graduate Programme:
Life Cycle in Medicine

Place:
Bygning 3, Room: Auditorium, Psykiatrihuset i Slagelse, Fælledvej 6, Stuen, 4200 Slagelse

Email address to gain access to the thesis: tamoor@hotmail.dk 
You will either receive a copy of the thesis or be informed where you can read a physical copy.

Short description of the thesis:
Childhood asthma is not one single disease, but a collection of different symptom patterns and immune mechanisms. This thesis explores how biomarkers and early-life symptoms can help identify clinically meaningful subgroups of children with asthma. Using data from the COPSAC birth cohorts, the studies examine blood immunoglobulin E, nasal inflammatory cytokines and early childhood cough and wheeze patterns in relation to type 2 inflammation, later asthma and lung development. The findings show that both biological markers and observable symptoms provide important, complementary information. Together, they may support more precise understanding of childhood asthma and help move future care towards better tailored assessment and treatment.