PhD defence by Ruixin Tao

RhoA - A Promising Lead in Alzheimer's Disease - APOE4 is instrumental in augmenting RhoA activation and contributes to Alzheimer's disease

Assessment Committee:
Associate professor Blanca Aldana, Department of Veterinary and Animal Sciences, University of Copenhagen (Chairperson)
Associate professor Mark Denham, Aarhus University, Denmark
Associate professor Henrietta Nielsen, Stockholm University, Sweden

Supervisors:
Professor Kristine Freude
Associate Professor Yonglun Luo

Department:
Department of Veterinary and Animal Sciences

Graduate Programme:
Neuroscience

Place:
Grønnegårdsvej 7, 1-04, Room: Auditorium A1-04.01, Grønnegårdsvej 7, 1870 Frederiksberg

Email address to gain access to the thesis: qxw392@sund.ku.dk 
You will either receive a copy of the thesis or be informed where you can read a physical copy.
Recipients of copies of the thesis are not allowed to share or distribute it due to copyright compliance.

Short description of the thesis:
Alzheimer's disease (AD) is the leading cause of dementia, yet the molecular mechanisms underlying AD remain incompletely understood. This thesis investigates how different Apolipoprotein E (APOE) genotypes, the strongest genetic risk factor for late-onset AD, cause APOE-dependent changes on RhoA activation, energy metabolism, neurite outgrowth, and Tau phosphorylation in pluripotent stem cell-derived neurons and astrocytes.The findings provide novel insights into the signaling that contributes to AD pathology and highlight potential molecular targets for future therapeutic intervention.