PhD defence by Patrick Terrence Brooks

High-resolution immunological profiling in allogeneic hematopoietic cell transplantation

Assessment Committee:
Professor Jens Ulrik Jensen, Department of Clinical Medicine, University of Copenhagen (Chairperson)
Professor Torben Barington, The University of Southern Denmark (SDU)
Professor Katarina le Blanc, Karolinska Institutet

Supervisors:
Clinical Professor Sisse Rye Ostrowski
Clinical Professor Henrik Sengeløv
MD Lars Klingen Gjærde, Clinical Associate Professor Hanne Vibeke Hansen Marquart, MD, PhD Lia Minculescu,

Department:
Department of Clinical Medicine

Graduate Programme:
Immunology and Infectious Diseases

Place:
8, Room: Einar Lundsgaard Auditoriet, Blegdamsvej 3B, DK-2200 København N

Email address to gain access to the thesis: ptbrooks@gmail.com
You will either receive a copy of the thesis or be informed where you can read a physical copy.

Short description of the thesis:
Allogeneic hematopoietic cell transplantation (allo-HCT) can cure life-threatening blood disorders, yet clinical outcomes remain highly dependent on successful immune reconstitution after treatment. This thesis investigates how advanced, high-resolution immune profiling can identify early biomarkers associated with survival, relapse, and transplant-related complications. By analyzing immune cell reconstitution, cytokine responses, and plasma proteomics in allo-HCT recipients, distinct immune signatures were linked to conditioning regimens and clinical outcomes. These findings demonstrate the value of multimodal immunodiagnostics in advancing our understanding of post-transplant immunity and highlight their potential to support more personalized, predictive, and effective care for patients undergoing allo-HCT.