PhD defence by Emily Eufaula Beaman

GPR125 in the central nervous system

Assessment Committee:
Associate professor Hanne Borger Rasmussen, Department of Biomedical Sciences, University of Copenhagen (Chairperson)
Associate professor Connar Stanley James Westgate, Technical University of Denmark and Danish Headache Centre, Rigshospitalet
Professor Dimitris Placantonakis, NYU Grossman School of Medicine

Supervisors:
Professor Mette Rosenkilde
Associate Professor Trine Lisberg Toft

Department:
Department of Biomedical Sciences

Graduate Programme:
Neuroscience

Place:
Panum, Room: 31.01.48a, Nørre Allé 20, 2200 København Ø

Email address to gain access to the thesis: emily.beaman@sund.ku.dk 
You will either receive a copy of the thesis or be informed where you can read a physical copy.

Short description of the thesis:
GPR125 is an orphan adhesion G protein-coupled receptor found throughout the body and brain. Within the central nervous system, its highest expression is in the choroid plexus, a tissue responsible for producing cerebral spinal fluid and maintaining a barrier between this and the peripheral blood stream.
This thesis explores the role of GPR125 in the brain using knockout mice, and investigates whether viral proteins can interact with this receptor and be used to deliver drugs to the central nervous system.