Super-Resolution Ultrasound Imaging of the Microvasculature – From Rat Kidneys to Human Lymph Nodes

PhD defence by Nathalie Sarup Panduro

Assessment Committee

Professor Andreas Kjær, Department of Biomedical Sciences, University of Copenhagen (Chairperson)
Associate professor Malene Roland Vils Pedersen, VIA University College, Herning
Dr Stefano Tarantini, The University of Oklahoma

Supervisors

Clinical Professor Michael Bachmann Nielsen
Professor Jørgen Arendt Jensen
Associate Professor Charlotte Mehlin Sørensen

Department

Department of Clinical Medicine

Graduate Programme

Medical and Molecular Imaging

Place

Building: Mærsk tower, Room: Holst auditorium, Blegdamsvej 3B, 2200 Copenhagen N

Email address to gain access to the thesis: nathalie.sarup.panduro.01@regionh.dk.
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Short description of the thesis

In many diseases, changes in the small blood vessels can reflect underlying pathology. However, the smallest vessels are beyond the spatial resolution of conventional ultrasound and are therefore difficult to visualize and characterize. This PhD thesis investigates super-resolution ultrasound, a new imaging technique that can reveal the microvasculature in greater detail. The research combines contrast-enhanced and contrast-free approaches and explores their use in both animal and human studies, from rat kidneys to normal and malignant lymph nodes. The findings demonstrate the potential of super-resolution ultrasound to provide detailed structural and functional information about the microvasculature, while also identifying important technical and physiological factors that need to be addressed to support further clinical translation.