PhD defence by Kathrine Vauvert Römmelmayer Hviid

Overweight and Reproductive Outcomes: The Role of GLP-1 Receptor Agonists and Preconceptional Weight Loss

Assessment Committee:
Professor Thomas Bergholt (Chairperson)
Professor Lars Henning Pedersen
Professor Siobhan Quenby

Supervisors:
Clinical Professor Henriette Svarre Nielsen
Clinical Professor Finn Stener Jørgensen
Associate professor Nina Rica Wium Geiker

Department:
Department of Clinical Medicine

Graduate Programme:
Life Cycle in Medicine

Place:
Panum, Room: Hannover Auditorie, Blegdamsvej 3B, 2200 Copenhagen N

Email address to gain access to the thesis: khvi0038@regionh.dk
You will either receive a copy of the thesis or be informed where you can read a physical copy.

Short description of the thesis:
Rising obesity and declining fertility are key health issues. Parental, especially maternal, obesity increases the risks for the child to develop obesity itself. Furthermore, obesity increases the risk of obstetric complications together with a longer time to pregnancy with natural conception or through fertility treatment. Weight loss before pregnancy, and possibly with new drugs like GLP-1 receptor agonists, may improve outcomes, but their safety in relation to reproduction and pregnancy is unclear. This PhD project aims to study pre-pregnancy weight loss, the effects of GLP-1 drugs before fertility treatment, and exposure of GLP-1 in the periconceptional period on obstetric outcomes.