Kick-off for Pharmacy Small Angle Scattering Hub

DRA symposium

The symposium has the goal to give an introduction on SAXS and SANS applied to pharma-related questions and give an overview of the applications of SAX/NS in the ongoing research at the Department.

Small-angle scattering (SAS) techniques have shown their strong capability in pharmaceutical sciences. However, even for the expert users, the experimental designing and data analysis are not necessarily optimised for each system routinely used within the department. Such observation is not unique here, and rather common in the SAS user community.

This presents our department an opportunity to form a cohesive SAS community to tackle many of the basic (e.g., sample preparation for nanoparticles and forming structure-activity relationships) and advanced challenges (e.g., developing novel data analysis, designing in-situ experiments, and deconvoluting scattering contributions). The establishment of Pharmacy Small Angle Scattering Hub (PSASH) aims to develop a technical support and collaborative community and increase the effective research impact of the department.

PSASH will kick-off with the DRA symposium, this will be a great opportunity for PhD students to meet expert SAS users and discuss the use of these techniques in their projects.

You can participate in Auditorium 3 or online via Zoom. Zoom link can be obtained by contacting Federica Sebastiani.

Programme

13:00 – 13:05

Introduction
Federica Sebastiani, Department of Pharmacy, UCPH, Denmark

Invited speaker from Large Scale Facility
13:05 – 14:05 SAXS and SANS in pharmaceutical science (tentative title)
Ann Terry, Group Manager, Diffraction and Scattering, Beamline Manager, CoSAXS Beamline MAX IV Laboratory, Lund University, Sweden
14:05 – 14:20 Coffee break
Clip session with contribution from IF researchers
14:20 – 14:30

Luna Gade Sørensen, PhD student
Phospholipase A2-responsive cubosomes for improved anti-inflammatory therapy
14:30 – 14:40

Sam Lenton / Marco Polimeni, postdoctoral researchers
Combining SAXS and simulations to investigate protein-protein interactions
14:40 – 14:50

Camilla Asgreen, PhD student
Treating skin infections with nanostructured liquid crystalline particles
14:50 – 15:00

Zahra Babaie, PhD student
Design of new 3D X-ray compatible microfluidic platform for online SAXS-on-chip characterization of nanomedicines
15:00 – 15:10

Zhenning Shi, PhD student
LPN and LNP structure SAXS and SANS (tentative)
15:10 – 15:20

Ragna Guldsmed Diedrichsen, postdoctoral researcher
Deep eutectic solvents for transdermal drug delivery: coupling solution structure with efficacy
15:20 – 15:30

Shinji Kihara, postdoctoral researcher
Understanding the nanoparticle-biomolecule corona structure using SAS techniques
15:30 – 16:00

Discussion and ideas for common BAG proposal to CoSAXS

The symposium is organized on behalf of the graduate programme in pharmaceutical sciences, Drug Research Academy, by Tenure Track Assistant Professor Federica Sebastiani, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen.

The symposium is free of charge and open for attendance by all interested parties.